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The bone density data comes from a secondary analysis of the same trial published in JAMA Network Open, showing that GLP-1 therapy alone decreased hip and spine BMD while the combination with exercise preserved it completely
However, they are most effective when combined with a well-rounded approach that includes lifestyle modifications and medical guidance
I should also note that a different semaglutide trial found a much higher fraction of people losing at least 5% of their body weight (92.5%) than the first figure above
It may also be a sign of other hormonal and autoimmune conditions, and rarely cancer
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