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Conclusion Our study is the first to demonstrate that HFD-induced impairment of testis first line of antioxidant defence, particularly SOD and GPx activity, had a significant impact to increase sperm and testicular oxidative DNA damage in rodents

Participants in this experiment complained of headache, fatigue, insomnia, intestinal disturbances, and numbness and tingling of their hands and feet (13)

The activity of t genes corresponds to regulon activity and pathway, where a higher score indicates a higher inferred level of genes, including HMGA1 and HMGB2 ( Figure 6E )

The goal is to regulate hormones, improve insulin sensitivity, and reduce associated health risks