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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

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In their study, titled Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica, published in the Journal of Neuroimmunology , researchers decided to study depression, fatigue and the use of l-carnitine in seventy-five patients with MS and 39 patients with NMO at Tohoku University Hospital in Japan