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Its the delayed response to a major change the body experienced months earlier

These modifications confer an extended elimination half-life of approximately 116.7 h, facilitating once-weekly dosing

Different stress conditions, including energy depletion, oxidative stress, and hyperosmolarity which emerge in many diseases and some genetic disorders, lead to shortening the erythrocyte lifespan thus facilitating the removal of the damaged and defective erythrocytes [134]