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But controlled human efficacy data is sparse, and the single Phase 2 trial tested oral administration rather than the subcutaneous injection most users employ today

What Happens if You Miss an Injection

Although inhibition of PDH activity by overproducing pyruvate dehydrogenase kinase 4 in INS-1 cells did not affect GSIS [35], it is possible that PDH may play a supportive role for GSIS by providing acetyl-CoA to condense with the oxaloacetate produced by PC, to form citrate for downstream shuttles

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