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Occurrence of gastrointestinal adverse events upon GLP-1 receptor agonist initiation with concomitant metformin use: A post hoc analysis of LEADER, STEP 2, SUSTAIN-6, and PIONEER 6
Doses should be spaced evenly throughout the day (every three or four hours) preferably during or following meals and should be consumed slowly in order to maximize tolerance
Additionally, the anus is richly supplied with nerve endings, making it highly sensitive to pressure and stretch
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