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A growing evidence base links higher UPF intake with obesity and worse health across multiple systems: Cardiometabolic & mortality risk: Umbrella review (~9.9M participants) links UPFs to 32 adverse outcomes including CVD mortality, T2D, depression, poor sleep, wheeze, obesity, and higher all-cause mortality (evidence ranges from convincing to suggestive)
Compounded versions are also unlawful
Retatrutide is generally well tolerated in controlled studies
In 2021, semaglutide was FDA-approved for this purpose, under the brand name Wegovy, and it has remained the target of extensive research, demonstrating remarkable results in clinical trials
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