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GLP-1s were also found to have significant weight loss benefits
In the SURMOUNT-5 head-to-head trial ( N Engl J Med , May 2025), tirzepatide produced 20.2% average weight loss compared to 13.7% with semaglutide over 72 weeks a 47% greater relative reduction
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When mixed with bacteriostatic water and stored at 36F 46F (2 8C), reconstituted semaglutide is generally stable for up to 28 days
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