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14 However, in two studies that included participants not enrolled in the SURPASS and SURMOUNT studies, ie, a large number of individuals who switched from other GLP-1 RAs to tirzepatide, those who transitioned from semaglutide experienced greater weight loss with tirzepatide treatment

In contrast, FOXO4-DRI leverages the elevated expression of FOXO4 and P53 in senescent cells by specifically blocking the interaction between FOXO4 and P53 to promote apoptosis via the P53 signaling pathway (Tao et al., 2016