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Although delivering a gene with a viral vector can alleviate the situation to some extent, it will bring extra stress on the cells, interact with endogenous cellular signal transduction components and cause cytotoxicity (Chen et al., 1999
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Sulforaphane produces antidepressant-and anxiolytic-like effects in adult mice. Behavioural brain research 301 (2016): 55-62
however, emerging data from both preclinical animal studies and phase II clinical trials show benefits of glucagon-like peptide-1 receptor agonists in halting the progression of PD
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