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| Cell Metabolism , 2008, 7, 45-56 | IF: 27.7 DOI: 10.1016/j.cmet.2007.10.013 The Challenge For years, the dominant model held that insulin resistance was caused by impaired mitochondrial oatty acid oxidation mitochondria were "broken," oat wasn't being burned, and lipids accumulated in muscle

These medications are typically administered by subcutaneous injection, either weekly (semaglutide, dulaglutide, tirzepatide) or daily (liraglutide), with dosing gradually increased over several weeks to minimize side effects

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