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This is counterintuitive but well-documented in bariatric medicine literature (Prado et al., Obesity Reviews , 2018)
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76 GST prodrugs appear to have a more favorable adverse-event profile, given that they are ingested as an inactive compound and undergo breakdown to release cytotoxic metabolites only in the presence of high concentrations of enzymes that occur in the proximity of tumor cells, thereby reducing collateral damage to healthy cells
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