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The FDA cited three concerns: potential immunogenicity (the peptide could trigger immune reactions), manufacturing impurity risks (synthetic peptides can contain truncated sequences and other contaminants), and a lack of human safety data sufficient to evaluate risk

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If blood sugar control remains a concern during the GLP-1 washout period, your physician may recommend older-generation diabetes medications like metformin, which has extensive safety data during pregnancy and is often continued into the third trimester if needed