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Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]
A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)
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Thus, researchers are advised to familiarize themselves with the preferred administration methods in each therapeutic context
