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Importantly, in phase I/IIa studies that include 41 postmenopausal patients, all of whom had advanced ER-positive breast cancer disease that had progressed after at least 6 months of endocrine therapy, GDC-0810 competed effectively with tracer to occupy the ER at all doses tested, even in patients with ESR1 mutations, suggesting robust target engagement ( Although the mechanism of action by GDC-0810 is not completely clear at this point, it is suspected that certain E3 enzymes are activated upon ER- engagement by the GDC compound, leading to its ubiquitination and degradation
Kress, J
A common approach: 5mg vial of BPC-157 Add 2ml of bacteriostatic water This gives 2500 mcg per ml A 250 mcg dose would be 0.1 ml (10 units on an insulin syringe) Store reconstituted BPC-157 in the refrigerator
F.HanX.RenJ.ZhanK
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