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Maguire, L
Interestingly, the infiltration of Th1 and Th17 cells into the CNS, as well as the secretion of cytokines by CD4+ T cells, could also be initiated by ferroptotic neurons, which were induced by over-expression of ACSL4 (a regulator of PUFA-PLs synthesis) (58)
ROS can be generated by overloading the mitochondrial oxidative phosphorylation system, and also by nicotinamide adenine dinucleotide phosphate oxidases (NOX) produced by either adipocytes, which only produce NOX4, or by macrophages, which produce mainly NOX2
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