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Common areas of study for IGF1 LR3 include growth factor signaling, protein synthesis pathways and cellular adaptive response mechanisms
This study used the NNMTi 5-amino-1-methylquinolinium (5A-M1Q), since our lab has set precedence using this probe molecule for proof-of-concept studies 8
The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study
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