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395 In other words, ZIP4 upregulated the expression of ZEB1 in PC, which in turn induced a substantial downregulation of gemcitabine uptake protein ENT1 by integrin 31, ultimately limiting drug internalization through activation of the MAP kinase JNK

In the glycolytic pathway, NAD+ facilitates the catalytic reactions of Glyceraldehyde-3-phosphate dehydrogenase (GADPH) and lactate dehydrogenase (LDH)