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A higher level of oxidative stress as evidenced by elevated plasma malondialdehyde levels and low levels of GSH, -tocotrienol and GSH peroxidase activity in patients under 45 years old may play a role in the development of premature coronary artery disease and be potential biomarkers for premature coronary artery disease (153)

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FIGURE 1 Light cues entrain the cerebral master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which in turn governs the nocturnal rise in melatonin secretion