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Rather than functioning as isolated antidepressant agents, these botanicals target complementary nodes within the interconnected pathophysiology of depressive disorders, encompassing monoaminergic dysregulation, impaired neurotrophic signaling, HPA-axis hyperactivity, neuroinflammation, oxidative stress, and mitochondrial dysfunction
Biochemically, once ferroptosis is activated, it cannot be suppressed by apoptosis, necrosis, or autophagy inhibitors but can be hidden by iron chelators such as deferoxamine (DFO) or antioxidants such as Trolox and fer-1
"Brain-Enhancing 'Smart Drugs' Are Going Commercial"
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