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doi:10.1097/CMR.0000000000000583.
In the PIONEER trial program, oral semaglutide 14 mg produced HbA1c reductions of approximately 1.0-1.4% and weight loss of 3-5 kg at 26-52 weeks, meaningful but below the efficacy achievable with injectable semaglutide 2.4 mg or tirzepatide
moreover, only a fraction of the normal gastric volume can be accommodated due to the greatly reduced gastric lumen
Linagliptin improved cell function with different efficacies in normal and diabetic islets Next we examined whether linagliptin affected glucose-stimulated insulin secretion (GSIS), a key feature of cell function, in human islets of different diabetic conditions
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