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Over time, this energy shortfall sets off a cascade of downstream effects: synaptic dysfunction, impaired protein clearance, neuroinflammation, and ultimately the accumulation of amyloid- and tau pathology Importantly, imaging and metabolic studies consistently show that reductions in cerebral glucose metabolism and perfusion precede cognitive symptoms by years, often decades [8]

And though they are less common, headaches and constipation are also potential side effects

Some researchers use microdosing strategies or split dosing approaches to manage dose-escalation side effects

Fine JP, Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk