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These mechanisms help reduce food intake and improve blood sugar control, making it an effective treatment for both diabetes and weight management
Besides, there are also studies based on the integrated analysis of 1 H nuclear magnetic resonance metabolomics and dynamic 13 C isotope tracer technology showing that FGF-21 intervention effectively remodeled glucose metabolism in the brain, facilitating the conversion of [ 113 C]-glucose to the key neurotransmitter precursor and energy metabolism intermediate [ 313 C]-lactate while restoring metabolic homeostasis to the -aminobutyric acidergic system [219]
For retatrutide, TRIUMPH-4 enrolled 445 adults living with obesity and knee osteoarthritis, and followed them for 68 weeks
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In addition, PCSK9 antibodies have shown an additive effect with statin therapy 9 and reduced the risk of cardiovascular events 10
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