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Insomnia and depression: clinical associations and possible mechanistic links

REDEFINE 11: a higher-dose follow-up Novo Nordisk has a higher-dose CagriSema trial (REDEFINE 11) running in parallel, expected to report in the first half of 2027

Weekly Metrics Worth Tracking Pain at rest (NRS 0 to 10), recorded at the same time each day (morning before activity works well) Pain with the most provocative exercise movement for that injury Range of motion at the affected joint, measured with a goniometer or a reliable phone app Functional milestones: for example, single-leg heel raise repetitions for Achilles tendinopathy, or overhead press weight for shoulder pathology When to Contact Your Prescriber Contact your prescriber if pain acutely worsens after a period of improvement, if you develop swelling or heat at the injury site suggesting possible infection (particularly if you are injecting locally), or if you notice any new and unexplained neurological symptoms such as numbness, tingling, or weakness in a limb

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