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Discussion This study highlights distinct protein expression profiles in gallbladder polyps and gallstones, offering valuable insights into the molecular mechanisms driving these conditions

This absence of foundational pharmacokinetic information constitutes a major knowledge gap with direct implications for clinical application, dosing strategies, and safety monitoring

While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches