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Frontiers in Pharmacology , 12, 627533

Rhonda Patrick: And as they take these drugs, that Mu opioid receptor becomes downregulated, and so you need more and more of the drug to feel as good as you did

It also helps maintain the barrier between the intestines and the rest of your body and aids with proper growth of intestinal cells

In the REDEFINE 1 trial, published in the New England Journal of Medicine, participants receiving the combination achieved 20.4% mean body weight reduction at 68 weeks