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This side effect is generally transient but should be monitored if: You experience palpitations Theres a noticeable, sustained increase over time Its advisable to have regular cardiac assessments while on GLP-1 medication, especially if you have underlying heart conditions

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Primary pathological features include hepatic fat accumulation, inflammation, fibrosis, and ballooning degeneration of hepatocytes

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Drug Disc 18 (4), 295317

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Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly prescribed in the UK for conditions such as rheumatoid arthritis, psoriasis, psoriatic arthritis, and certain inflammatory bowel diseases

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