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GLP-1R/GCGR dual agonism-induced improvement in insulin sensitivity confers lower insulin secretory demand on the pancreatic -cell To examine whether the cotadutide-induced improvement in insulin sensitivity and glucose lowering confers changes in -cell insulin secretory function and endocrine pancreas morphology, we treated 2 cohorts of DIO mice with vehicle or cotadutide for 28 days, which resulted in significantly lower BW (~ 20%) in cotadutide-treated mice (Fig

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Beyond its primary use in diabetes, the weight-loss effects of Ozempic, observed in clinical trials, led to further exploration of the drugs potential in this area

This is the most comprehensive review to date of longterm cardiovascular outcome trials for GLP1 receptor agonists, lead author Simon Cork said in a press release