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While others battle sudden vomiting, bloating, diarrhea, or painful constipation, these symptoms usually peak during the increase in dose
Scheme 21
By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model
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