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GIP receptor activation enhances insulin secretion, modulates adipose tissue metabolism, and appears to synergise with GLP-1 activity to produce greater metabolic effects than either hormone alone as demonstrated by the clinical performance of the dual agonist tirzepatide
However, the benefits of taking these drugs should be weighed against these risks when the medications are prescribed
GLP-3 style medications, also called triple agonists, are being studied because they may activate GLP-1, GIP, and glucagon pathways
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