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NLRP3 inflammasome is activated by toll-like receptor (TLR) activation, NFB, or some PAMPs and DAMPs resulting in maturation and production of cytokines such as IL-1, which is the primary inflammatory protein involved in inflammatory pathways (Jo et al., 2016)

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TB-500 (Thymosin 4) is a naturally occurring peptide that regulates actin polymerization, promotes cell migration, reduces inflammation, and supports wound healing and tissue regeneration [3] [4]