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Whilst efficiency can improve yields to a certain extent, the only option is to expand capacity. Talking about the complexity of Novos purification process, Henry added, It was highly unlikely for Novo to either consider reallocating existing insulin fermentation capacity or be willing to disclose know-how of its fermentation process to a third party. A contract development and manufacturing organization (CDMO) could theoretically do it, but this would take enormous investment to replicate the complexity required for fermentation & purification (relative to the less complex peptide process used by Lilly)." To remedy this issue and accommodate the increasing demand in the US, Catalent could play a crucial role for the company

The first step is a thorough evaluation to identify contributing factors

Longer needles (6-8mm) may be necessary for areas with very thick subcutaneous tissue