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Insulin resistance: the same meal can trigger a higher glucose and insulin response, making fat easier to store and harder to lose

acts centrally to reduce appetite Setmelanotide : Reserved for specific genetic obesity syndromes (e.g., POMC/PCSK1/LEPR deficiency, Bardet-Biedl syndrome) under specialist supervision Non-pharmacological interventions form the cornerstone of weight management and may be particularly appropriate: Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, increased physical activity, and behavioural strategies

Standard Target: 600800 mcg daily by Weeks 58

+ Absolutely