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The initial months include the escalation phase where doses are sub-therapeutic, so dramatic early results should not be expected

Besides, FGF21 increased insulin content in primary islets in a rat model of type 2 diabetes [32] and increased beta cell number in a mouse model of type 2 diabetes [33, 34]

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Ipamorelin Dosing Schedule (Community-Derived) Phase Assessment Timing Week 1 Daily Dose 100 mcg/day Frequency 1x at bedtime, fasted Phase Titration Timing Weeks 2-3 Daily Dose 200 mcg/day Frequency 1x bedtime, or split 100 mcg AM + 100 mcg PM Phase Standard Timing Weeks 4-8 Daily Dose 200-300 mcg/day Frequency 1-2x daily (AM fasted + bedtime is common) Phase Extended Timing Weeks 9-12 Daily Dose 200-300 mcg/day Frequency Continue if tolerated