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This work was supported by grants from the National Natural Science Foundation of China (12032007, 31971242)
Users with longer treatment duration (6+ months) typically stabilize at plateau maintaining 40-60% of peak improvements, while short-term users (under 3 months) often continue gradual decline approaching pre-treatment baseline by month 4-6
The FDA considers 5% weight loss clinically meaningful, and a drug must demonstrate a statistically significant advantage over placebo on this categorical measure
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