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Baseline IGF-1 level and age are the strongest predictors of magnitude
[25] [26] Based on its overexpression in a majority of human tumor cell lines and prevalence in chemotherapeutic-resistant tumors, GSTP1-1 is thought to play a role in the development of cancer and its potential resistance to drug treatment
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These synthetic forms are not biologically active in the same way as the natural L-isomer and can actually competitively inhibit the absorption and utilization of naturally occurring L-carnitine, potentially inducing a state of carnitine deficiency and worsening fatigue symptoms
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