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Researchers believe this combined mechanism may explain why trial participants experienced greater average weight loss compared with earlier GLP-1 therapies

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Patients with metabolic comorbidities: Autoimmune patients with concurrent insulin resistance, metabolic syndrome, or cardiovascular risk factors benefit doubly, since the GLP-1 addresses both the autoimmune inflammation and the metabolic burden

Both are also indicated for the protection of the heart in patients who have excess weight or type 2 diabetes, respectively