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We are going to explore the molecular and cellular pathways through which oxidative stress promotes the breakthrough and advancement of chronic illness, including cardiovascular disorders, diabetes, Alzheimers and Parkinsons disease, chronic inflammatory conditions, and cancer
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Increases in extracellular K + mediated by neuronal activities, along with vasoconstrictors such as endothelin 1 (ET1), PDGFB, and blood-derived insulin-like growth factor 1 (IGF1), trigger Ca 2+ entry into pericytes through VGCCs, causing depolarization and contraction [7, 93]
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