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On a structural level, several brain regions show altered development

Cell Death Dis 2020;11:73

95 SchmidtT

Phosphorylation of Y1135 and Y1131 destabilises the autoinhibitory conformation of the a-loop, whereas phosphorylation of Y1136 stabilises the catalytically optimised conformation of it (Favelyukis et al, 2001)