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Joint pain developing after starting B12 may reflect: Pre-existing musculoskeletal conditions becoming more noticeable Concurrent inflammatory or degenerative joint disease Reactions to excipients in certain formulations The natural course of an underlying condition If you experience persistent or worsening joint symptoms after beginning B12 supplementation, it is advisable to consult your GP or healthcare provider

European Journal of Nutrition , 54(2), 251263.

Longevity and maintenance The effects achieved may require continued treatment to maintain, and the discontinuation of treatment could result in a gradual return to normal skin tone