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In APP/PS1 transgenic mice, the standard animal model for Alzheimer disease pathology, Dihexa restored spatial learning to levels indistinguishable from healthy controls

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A way to explain cell death associated with reduced levels of GSH is ferroptosis, a unique iron-dependent form of non-apoptotic cell death, characterized by lipid peroxidation with ROS accumulation due to GSH peroxidase inactivation and high levels of GSH consumption

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