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Average weight loss ranges from 9.2-12.4 kg (20-27 pounds) over 68 weeks, with most patients seeing noticeable results by 12 weeks

Findings suggest this interaction may trigger signal cascades involving second messengers such as cAMP, leading to downstream transcriptional activity related to GH synthesis

Therefore, to eliminate the potential baseline effect of different studies, the rates of body weight change from the initial values were selected as the therapeutic index, which was a better indicator used to assess changes in body weight