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For instance, in Table 3 , antioxidants at different levels improved semen quality parameters like mitochondrial activity, sperm motility, and enhanced the functionality of seminal plasma, decreased MDA levels

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Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene