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SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1
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FIGURE 1 3.1 Abnormality of the PI3K/AKT signaling pathway mediates the development of IR in PCOS Under normal circumstances, the tyrosine residues of the -subunit of the insulin receptor undergo autophosphorylation upon the binding of insulin to its receptor, activating the receptor (Sun et al., 1991)
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