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Real medications
Feeding different ATP-producing pathways
This means that only a small fraction of the drug reaches the bloodstream, necessitating higher doses or special formulations in order to achieve the desired therapeutic effect
The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)
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