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The Warburg effect indicates that regardless of the oxygen availability, the metabolic reprogramming in tumor cells will inhibit oxidative phosphorylation of mitochondria, so the utilization of glucose tends to be anaerobic glycolysis, rather than aerobic oxidation, which will lead to the accumulation of lactate [14]

Diabetes Obes Metab 22(12):23642374

In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%