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Presented for research literature review only Kendall RV (1994)
The exact mechanism for this is not fully established, but hypotheses include compensatory responses to blood pressure reduction or direct effects on autonomic tone
Weight Loss Efficacy: Head-to-Head Trial Data (SURMOUNT-5) The most reliable comparison comes from SURMOUNT-5, the first randomized, head-to-head trial directly comparing the two drugs in the same patient population (751 adults with obesity, no diabetes) over 72 weeks: Tirzepatide also produced greater improvements in blood pressure, HbA1c, fasting insulin, triglycerides, and HDL cholesterol at 72 weeks
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