The invention has the following advantages: (1) the final product prepared by the invention is a product which is quantitatively frozen and dried in a tube-shaped bottle according to the product specification, and the invention adopts a repeated freezing and thawing process, has white and porous block appearance, better stability and less single impurity and total impurity
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doi: 10.1007/978-981-10-5311-5_20
In a recent study by Fiore et al., inhibition of IDO1 sensitized cancer cells to ferroptosis, leading to increased cell death in vitro and reduced tumor growth in vivo ( Inhibition of IDO1 and TDO2: a promising therapeutic strategy The failure of single-agent IDO1 inhibitors, such as epacadostat, in clinical trials highlighted the limitations of targeting a single enzyme in the kynurenine pathway ( Table 1 )