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When standard, unformulated glutathione is ingested, the highly acidic environment of the stomach (which has a pH of less than 1.5) and the aggressive digestive enzymes (peptidases) in the small intestine rapidly cleave the tripeptide into its three constituent amino acids
In some individuals, usually adults, acetaminophen can induce a high-anion-gap metabolic acidosis secondary to 5-oxoproline (ie, acquired pyroglutamic academia), possibly because of a genetically determined propensity (54
Lactobacillus and Bifidobacterium produce lactic acid and acetic acid that reduce intestinal pH, creating an unfavourable environment for the survival of pathogenic bacteria and suitable for the rebalancing of intestinal flora
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