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How to Rationally Approach Supplementation for Sleep, Hormone Support, and Cognitive Enhancement Sleep Huberman suggests that if youre thinking about supplementation for sleep, you first need to optimize your behavioral and nutritional protocols, such as avoiding caffeine after 2 pm and avoiding food two hours before bed, as these can disrupt the architecture of sleep. Once these protocols are met, Huberman says you need to ask yourself a few questions

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SHBG Changes Weight loss and improved metabolic health may increase sex hormone-binding globulin (SHBG), which helps regulate circulating testosterone and supports a healthier balance of free (active) hormone

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